Study type: In vivo/preclinical · Status: Verified against declared source

The Anxiolytic Drug Buspirone Prevents Rotenone-Induced Toxicity in a Mouse Model of Parkinson's Disease.

International journal of molecular sciences · 2022

Study scale: Buspirone is clinically used as an anxiolytic and has been previously utilised as a positive control in the assessment of the exploratory behaviour of C57BL/6 mice in the open field (OF) [20] (Supplementary Figure S1).

Abstract only: Open source record

Product or molecular entity relationships

VIP: Exact entity relationship. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.

Plain-language verified summary

Question

Seventy-two 7-week-old C57BL/6 male mice were purchased from ARC (Perth, WA, Australia) (Table 1).

Methods

Several studies have described behavioural deficits in mice after systemic administration or rotenone [23,24,25,26].

Scale or participants

Buspirone is clinically used as an anxiolytic and has been previously utilised as a positive control in the assessment of the exploratory behaviour of C57BL/6 mice in the open field (OF) [20] (Supplementary Figure S1).

Key findings

A pharmacological and genetic blockade of the dopamine D3 receptor (D3R) has shown to be neuroprotective in models of Parkinson’s disease (PD).

Limitations and uncertainty

Drug-induced effects on locomotor behaviour were also appraised by comparing the total distance travelled (Figure 1D) and the average speed (Figure 1E).

Verified against declared source. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.