Study type: In vitro · Status: Verified against declared source
S14G-humanin restored cellular homeostasis disturbed by amyloid-beta protein.
PubMed · 2013
Study scale: Not reported
Abstract only: Open source record
Product or molecular entity relationships
- Humanin: Exact entity relationship. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.
Plain-language verified summary
Question
Research background: Humanin can effectively protect neuronal cells against nearly all Alzheimer's disease insults, such as neurotoxic Aβ peptides (Aβ1–42 and Aβ1–43).
Methods
Not reported in the reviewed source.
Scale or participants
Not reported in the reviewed source.
Key findings
Humanin is a potential therapeutic agent for Alzheimer's disease, and its derivative, S14G-humanin, is 1 000-fold stronger in its neuroprotective effect against Alzheimer's disease-relevant insults.
Limitations and uncertainty
(2) This study concluded that S14G-humanin blocks the action of amyloid-beta protein on neuronal membrane and restores perturbed cellular homeostasis, thereby alleviating the neurotoxic effects of amyloid-beta protein on hippocampal neurons.
Verified against declared source. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.