Study type: Human research · Status: Verified against declared source

Sniffing around oxytocin: review and meta-analyses of trials in healthy and clinical groups with implications for pharmacotherapy

Translational Psychiatry · 2013

Study scale: The popularity of oxytocin (OT) has grown exponentially during the past decade, and so has the number of OT trials in healthy and clinical groups.

Abstract only: Open source record

Product or molecular entity relationships

  • Oxytocin: Exact entity relationship. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.

Plain-language verified summary

Question

Since 20 years trials have involved clinical groups as well, including patients with autism spectrum disorders, depression, social anxiety, schizophrenia, obsessive-compulsive problems, borderline personality disorder and post-traumatic stress disorder.

Methods

The first study on levels of salivary OT after intranasal administration showed that levels remained highly elevated for more than 2 h.26 The second study found increased salivary OT levels for the whole 4-h period that assessments took place.27 A third study followed the participants up to 7 h after intranasal administration of OT or placebo.28 In the placebo condition, salivary OT levels were highly correlated over time, indicating impressive individual stability over the day.

Scale or participants

The popularity of oxytocin (OT) has grown exponentially during the past decade, and so has the number of OT trials in healthy and clinical groups.

Key findings

The popularity of oxytocin (OT) has grown exponentially during the past decade, and so has the number of OT trials in healthy and clinical groups.

Limitations and uncertainty

The popularity of oxytocin (OT) has grown exponentially during the past decade, and so has the number of OT trials in healthy and clinical groups.

Verified against declared source. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.