Study type: In vivo/preclinical · Status: Verified against declared source

Role of VPAC1 and VPAC2 receptors in the etiology of pregnancy rhinitis: an experimental study in rats.

Brazilian journal of otorhinolaryngology · 2022

Study scale: PR is a relatively common sex hormone-related ORL disorder.

Abstract only: Open source record

Product or molecular entity relationships

VIP: Exact entity relationship. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.

Plain-language verified summary

Question

The receptors VPAC1 and VPAC2 are known for their roles in allergic rhinitis.

Methods

Total RNA extraction was carried out from the laryngeal mucosa with using TRIzol® Reagent in the combination with the PureLink® RNA Mini Kit (Thermo Fisher Scientific, 12183555).

Scale or participants

PR is a relatively common sex hormone-related ORL disorder.

Key findings

VPAC1 and VPAC2 were found to be in all layers of septal specimens, but the immunostaining of surface epithelium was more distinct in specimens of both groups.

Limitations and uncertainty

PR leads to a predisposition to snoring and even obstructive sleep apnea syndrome, which induces some maternal and fetal morbidities.9, 10, 11 The pathophysiology of PR is still not fully understood.

Verified against declared source. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.