Study type: In vitro · Status: Verified against declared source
Evaluation of antimicrobial chemical sequence LL-37 for treatment of Staphylococcus aureus biofilm on titanium plate.
Medicine · 2021
Study scale: Antimicrobial peptides are a class of active antigens induced by the biological immune system, which can resist the infection of a variety of pathogens and are an important part of the innate immune system of multicellular organisms.[1] Compared with traditional antibiotics, antimicrobial peptides have the advantages of broad antibacterial spectrum and faster bactericidal rates.[2,3] With the emergence of antibiotic-resistant strains in large numbers, the application of antimicrobial peptides as a new antibacterial agent in clinical treatment has aroused many scholars’ interest, also provided a new idea and means for the treatment of clinical infection.[4–9] Clinically, 80% of human bacterial infections are in the form of biofilm.
Abstract only: Open source record
Product or molecular entity relationships
- LL-37: Exact entity relationship. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.
Plain-language verified summary
Question
In this study, the in vitro antibacterial activity of LL-37 on S.
Methods
Antimicrobial peptides are a class of active antigens induced by the biological immune system, which can resist the infection of a variety of pathogens and are an important part of the innate immune system of multicellular organisms.[1] Compared with traditional antibiotics, antimicrobial peptides have the advantages of broad antibacterial spectrum and faster bactericidal rates.[2,3] With the emergence of antibiotic-resistant strains in large numbers, the application of antimicrobial peptides as a new antibacterial agent in clinical treatment has aroused many scholars’ interest, also provided a new idea and means for the treatment of clinical infection.[4–9] Clinically, 80% of human bacterial infections are in the form of biofilm.
Scale or participants
Antimicrobial peptides are a class of active antigens induced by the biological immune system, which can resist the infection of a variety of pathogens and are an important part of the innate immune system of multicellular organisms.[1] Compared with traditional antibiotics, antimicrobial peptides have the advantages of broad antibacterial spectrum and faster bactericidal rates.[2,3] With the emergence of antibiotic-resistant strains in large numbers, the application of antimicrobial peptides as a new antibacterial agent in clinical treatment has aroused many scholars’ interest, also provided a new idea and means for the treatment of clinical infection.[4–9] Clinically, 80% of human bacterial infections are in the form of biofilm.
Key findings
However, there are few studies on LL-37 in S.
Limitations and uncertainty
However, there are few studies on LL-37 in S.
Verified against declared source. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.