Study type: Human research · Status: Verified against declared source

Glutathione Is a Key Player in Metal-Induced Oxidative Stress Defenses

2012

Study scale: The primary response of plants to metal stress is the generation of reactive oxygen species (ROS) such as superoxide (O2 •−), hydrogen peroxide (H2O2) and the hydroxyl radical (HO•), the major contributors to oxidative damage [95,96].

Abstract only: Open source record

Product or molecular entity relationships

Glutathione: Exact entity relationship. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.

Plain-language verified summary

Question

Metals are natural components of the earth’s crust; low background concentrations can be detected in soils, sediments, waters and even in organisms.

Methods

Metals are natural components of the earth’s crust; low background concentrations can be detected in soils, sediments, waters and even in organisms.

Scale or participants

The primary response of plants to metal stress is the generation of reactive oxygen species (ROS) such as superoxide (O2 •−), hydrogen peroxide (H2O2) and the hydroxyl radical (HO•), the major contributors to oxidative damage [95,96].

Key findings

Since the industrial revolution, the production, and consequently the emission of metals, has increased exponentially, overwhelming the natural cycles of metals in many ecosystems.

Limitations and uncertainty

Glutathione (γ-glutamyl-cysteinyl-glycine) is a widely distributed tripeptide found at millimolar concentrations (0.5–10 mM) in plant cells [19].

Verified against declared source. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.