Study type: Human research · Status: Verified against declared source
Targeting Glutathione Metabolism: Partner in Crime in Anticancer Therapy
2019
Study scale: Glutathione (GSH) is the predominant low-molecular-weight antioxidant with a ubiquitous distribution inside the cell.
Abstract only: Open source record
Product or molecular entity relationships
- Glutathione: Exact entity relationship. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.
Plain-language verified summary
Question
Glutathione (GSH) is the predominant low-molecular-weight antioxidant with a ubiquitous distribution inside the cell.
Methods
The most straightforward strategy to decrease GSH level is the use of buthionine sulfoximine (BSO), the irreversible inhibitor of the enzyme catalysing the first and limiting step of GSH synthesis, GCL.
Scale or participants
Glutathione (GSH) is the predominant low-molecular-weight antioxidant with a ubiquitous distribution inside the cell.
Key findings
Glutathione (GSH) is the predominant low-molecular-weight antioxidant with a ubiquitous distribution inside the cell.
Limitations and uncertainty
In 2003, a high-throughput synthetic lethality screening by Stockwell’s group identified a synthetic lethal interaction between cells expressing oncogenic Harvey rat sarcoma viral oncogene homolog (HRAS) and erastin [73].
Verified against declared source. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.