Study type: In vivo/preclinical · Status: Verified against declared source

Cell-type-specific imaging of neurotransmission reveals a disrupted excitatory-inhibitory cortical network in isoflurane anaesthesia.

EBioMedicine · 2021

Study scale: General anaesthesia is widely applied in clinical practice, and the estimated number of surgical procedures worldwide exceeds 300 million each year [1].

Abstract only: Open source record

Product or molecular entity relationships

VIP: Exact entity relationship. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.

Plain-language verified summary

Question

Mice were placed on the head-fixation apparatus.

Methods

General anaesthesia is widely applied in clinical practice, and the estimated number of surgical procedures worldwide exceeds 300 million each year [1].

Scale or participants

General anaesthesia is widely applied in clinical practice, and the estimated number of surgical procedures worldwide exceeds 300 million each year [1].

Key findings

We found a general decrease in cortical GABA transmission during aLOC.

Limitations and uncertainty

We found a general decrease in cortical GABA transmission during aLOC.

Verified against declared source. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.