Study type: In vivo/preclinical · Status: Verified against declared source

Histochemical Characterization of the Dorsal Raphe-Periaqueductal Grey Dopamine Transporter Neurons Projecting to the Extended Amygdala.

eNeuro · 2022

Study scale: Digoxigenin (DIG)-labeled antisense riboprobes were made from cDNAs of mouse DAT (nucleotides of 2–210, GenBank accession number: NM_010020.3).

Abstract only: Open source record

Product or molecular entity relationships

VIP: Exact entity relationship. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.

Plain-language verified summary

Question

Therefore, in the present study, we aimed to clarify the potential heterogeneity of DADR-PAG neurons projecting to the CeA and BNST.

Methods

Therefore, in the present study, we aimed to clarify the potential heterogeneity of DADR-PAG neurons projecting to the CeA and BNST.

Scale or participants

Digoxigenin (DIG)-labeled antisense riboprobes were made from cDNAs of mouse DAT (nucleotides of 2–210, GenBank accession number: NM_010020.3).

Key findings

Dopaminergic (DA) neurons in the dorsal raphe (DR) and periaqueductal gray (PAG) regions have projections to the extended amygdala and have been reported to modulate various affective behaviors.

Limitations and uncertainty

Dopaminergic (DA) neurons in the dorsal raphe (DR) and periaqueductal gray (PAG) regions have projections to the extended amygdala and have been reported to modulate various affective behaviors.

Verified against declared source. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.