Study type: In vitro · Status: Verified against declared source
Protective Effect of Glutathione against Oxidative Stress-induced Cytotoxicity in RAW 264.7 Macrophages through Activating the Nuclear Factor Erythroid 2-Related Factor-2/Heme Oxygenase-1 Pathway
2019
Study scale: Glutathione (GSH) is a ubiquitous thiol-containing tripeptide that consists of L-cysteine, L-glutamic acid, and glycine, and it is one of the most studied cell antioxidants currently being researched [10,11,12,13].
Abstract only: Open source record
Product or molecular entity relationships
- Glutathione: Exact entity relationship. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.
Plain-language verified summary
Question
Reactive oxygen species (ROS), products of oxidative stress, contribute to the initiation and progression of the pathogenesis of various diseases.
Methods
We subsequently performed three assays to determine whether glutathione prevents DNA damage.
Scale or participants
Glutathione (GSH) is a ubiquitous thiol-containing tripeptide that consists of L-cysteine, L-glutamic acid, and glycine, and it is one of the most studied cell antioxidants currently being researched [10,11,12,13].
Key findings
Reactive oxygen species (ROS), products of oxidative stress, contribute to the initiation and progression of the pathogenesis of various diseases.
Limitations and uncertainty
Reactive oxygen species (ROS), products of oxidative stress, contribute to the initiation and progression of the pathogenesis of various diseases.
Verified against declared source. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.