Study type: In vitro · Status: Verified against declared source

Mammalian histones facilitate antimicrobial synergy by disrupting the bacterial proton gradient and chromosome organization.

Nature communications · 2020

Study scale: Electrocompetent MG1655 were prepared by culturing in SOB to an OD600 of 0.2 to 0.5, washing with 10% chilled glycerol 4 times, resuspending to an OD600 of 0.2, and freezing at −80 °C.

Abstract only: Open source record

Product or molecular entity relationships

LL-37: Exact entity relationship. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.

Plain-language verified summary

Question

a Fluorescence and phase-contrast images of E.

Methods

The inability to recover from cell damage may reflect the specific combination of H2A with AMP-induced pores.

Scale or participants

Electrocompetent MG1655 were prepared by culturing in SOB to an OD600 of 0.2 to 0.5, washing with 10% chilled glycerol 4 times, resuspending to an OD600 of 0.2, and freezing at −80 °C.

Key findings

First proposed as antimicrobial agents, histones were later recognized for their role in condensing chromosomes.

Limitations and uncertainty

First proposed as antimicrobial agents, histones were later recognized for their role in condensing chromosomes.

Verified against declared source. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.