Study type: In vitro · Status: Verified against declared source
Ocular and systemic bio-distribution of rhodamine-conjugated liposomes loaded with VIP injected into the vitreous of Lewis rats.
Molecular vision · 2007
Study scale: At the level of the internal retina, rare liposomes were internalized by ED1-positive ramified microglial cells (Figure 1A).
Abstract only: Open source record
Product or molecular entity relationships
- VIP: Exact entity relationship. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.
Plain-language verified summary
Question
Local delivery of therapeutic molecules encapsulated within liposomes is a promising method to treat ocular inflammation.
Methods
Local delivery of therapeutic molecules encapsulated within liposomes is a promising method to treat ocular inflammation.
Scale or participants
At the level of the internal retina, rare liposomes were internalized by ED1-positive ramified microglial cells (Figure 1A).
Key findings
Liposomes are specifically internalized by retinal Müller glial cells and resident macrophages in the eye.
Limitations and uncertainty
Liposomes are specifically internalized by retinal Müller glial cells and resident macrophages in the eye.
Verified against declared source. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.