Study type: In vivo/preclinical · Status: Verified against declared source

Anti-Psoriatic Effects of Middle Fragment of Chlamydial Plasmid-Encoded Protein pGP3 in an Imiquimod-Induced Psoriasis Mouse Model.

Medical science monitor : international medical journal of experimental and clinical research · 2021

Study scale: BALB/c female mice (6–8 weeks old) were purchased from Tianjin Oid Laboratory Products (Tianjin, China).

Abstract only: Open source record

Product or molecular entity relationships

LL-37: Exact entity relationship. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.

Plain-language verified summary

Question

Not reported in the reviewed source.

Methods

In a previous study, it was found that chlamydial plasmid-encoded protein pGP3 can neutralize the antichlamydial activity of LL-37 peptide by binding.

Scale or participants

BALB/c female mice (6–8 weeks old) were purchased from Tianjin Oid Laboratory Products (Tianjin, China).

Key findings

Previously, we demonstrated that the chlamydial protein pGP3 forms a stable complex with LL-37 to neutralize its proinflammatory activity during the pathogenesis of psoriasis.

Limitations and uncertainty

The histological features of the HE-stained dorsal skin sections of the IMQ group were consistent with the skin manifestations and PASI scores.

Verified against declared source. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.