Study type: Human research · Status: Verified against declared source
Effects of route of administration on oxytocin-induced changes in regional cerebral blood flow in humans
2020
Study scale: Upper panel—Drug allocation scheme: In each session, participants received treatment via all three administration routes, in one of two fixed sequences: either nebulizer/intravenous infusion/standard nasal spray, or standard nasal spray/intravenous infusion/nebulizer.
Abstract only: Open source record
Product or molecular entity relationships
- Oxytocin: Exact entity relationship. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.
Plain-language verified summary
Question
Could nose-to-brain pathways mediate the effects of peptides such as oxytocin (OT) on brain physiology when delivered intranasally?
Methods
Could nose-to-brain pathways mediate the effects of peptides such as oxytocin (OT) on brain physiology when delivered intranasally?
Scale or participants
Upper panel—Drug allocation scheme: In each session, participants received treatment via all three administration routes, in one of two fixed sequences: either nebulizer/intravenous infusion/standard nasal spray, or standard nasal spray/intravenous infusion/nebulizer.
Key findings
Could nose-to-brain pathways mediate the effects of peptides such as oxytocin (OT) on brain physiology when delivered intranasally?
Limitations and uncertainty
Human studies almost exclusively target the central OT system by administering synthetic OT using nasal sprays, despite a lack of understanding of the mechanisms underpinning its pharmacodynamic effects.
Verified against declared source. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.