Study type: In vitro · Status: Verified against declared source
The pathogenic Th profile of human activated memory Th cells in early rheumatoid arthritis can be modulated by VIP.
Journal of molecular medicine (Berlin, Germany) · 2015
Study scale: Immune memory facilitates the maintenance of health by preventing repeated infections but, if it becomes deregulated, it can also lead to chronic inflammation.
Abstract only: Open source record
Product or molecular entity relationships
- VIP: Exact entity relationship. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.
Plain-language verified summary
Question
Our aim is to study the behavior of memory Th cells (Th17, Th17/1, and Th1 profiles) from early rheumatoid arthritis (eRA) patients after their in vitro activation/expansion to provide information about its contribution to RA chronicity.
Methods
As Th17 and Th1 are important in the pathogenesis of RA, the study of the effect of microenvironment mediators could be important to the design of therapies for their modulation.
Scale or participants
Immune memory facilitates the maintenance of health by preventing repeated infections but, if it becomes deregulated, it can also lead to chronic inflammation.
Key findings
Our aim is to study the behavior of memory Th cells (Th17, Th17/1, and Th1 profiles) from early rheumatoid arthritis (eRA) patients after their in vitro activation/expansion to provide information about its contribution to RA chronicity.
Limitations and uncertainty
Immune memory facilitates the maintenance of health by preventing repeated infections but, if it becomes deregulated, it can also lead to chronic inflammation.
Verified against declared source. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.