Cortagen

Public identity

Publication state

unpublished

Sequence

Ala-Glu-Asp-Pro

Available variants

Analytical boundary

Representative catalog purity: 99.5%

No active-batch certificate of analysis is currently published.

Purity figures shown here are representative catalog specifications, not lot-specific measurements.

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Evidence inventory

Record state

citation records

Public records

34

Reviewed summaries

0

Verified citations

0

• Human study: 0
• In vivo: 22
• In vitro: 12
• Special category: 0
• Unclassified: 0

These counts describe linked records and review status. They do not establish efficacy, safety, or fitness for any use.

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Technical record

Molecular weight

530.6 Da

Sequence class

peptide

Appearance

Lyophilized Solid

Solubility

Water, PBS, or 0.9% NaCl

Mechanism record

Cortagen (Ala-Glu-Asp-Pro) is a Khavinson 4-residue chemical sequence bioregulator with tissue-specific affinity for cortical neurons and CNS tissue. It penetrates nuclear membranes and interacts with AT-rich DNA regions in genes involved in neuronal survival, synaptic plasticity, and antioxidant defense. Demonstrated neuroprotective effects against oxidative stress-induced neuronal apoptosis and age-related cognitive decline in preclinical models.

Half-life record

~20–30 minutes (SubQ, plasma)

Recorded receptors

• Cortical neuron receptors
• CNS gene expression modulators

External literature records

1. External literature record

Limitations and research boundary

Research use only. Not for human or veterinary use. Public catalog information is limited to chemical identity, analytical documentation, and external reference records.

External records are attributed references. Their presence does not convert a source-reported observation into a product claim.