Dihexa

Public identity

Publication state

unpublished

Sequence

N-hexanoyl-Tyr-Ile-(6)-aminohexanoic amide

Available variants

Analytical boundary

Representative catalog purity: 99.2%

No active-batch certificate of analysis is currently published.

Purity figures shown here are representative catalog specifications, not lot-specific measurements.

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Evidence inventory

Record state

reviewed records

Public records

17

Reviewed summaries

1

Verified citations

0

• Human study: 4
• In vivo: 11
• In vitro: 2
• Special category: 0
• Unclassified: 0

These counts describe linked records and review status. They do not establish efficacy, safety, or fitness for any use.

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Technical record

Molecular weight

462.6 Da

Sequence class

peptidomimetic

Appearance

Lyophilized Solid

Solubility

Water, PBS, or 0.9% NaCl

Mechanism record

Dihexa (N-hexanoic-Tyr-Ile-(6)-aminohexanoic amide) is a modified angiotensin IV analog ~7 orders of magnitude more potent than BDNF at promoting HGF/c-Met receptor dimerization. It activates HGF/c-Met → PI3K/Akt signaling to promote dendritic spine formation, synaptic connectivity, and memory consolidation. Also binds AT4 receptors (IRAP) on hippocampal neurons.

Half-life record

~10 hours (oral, plasma)

Recorded receptors

• HGF/c-Met
• AT4 (angiotensin IV)

External literature records

1. External literature record
2. External literature record

Limitations and research boundary

Research use only. Not for human or veterinary use. Public catalog information is limited to chemical identity, analytical documentation, and external reference records.

External records are attributed references. Their presence does not convert a source-reported observation into a product claim.