Research chemical sequence
LL-37
LL-37 is listed as a research-use-only chemical sequence. Research use only. Not for human or veterinary use. Public catalog information is limited to chemical identity, analytical documentation, and external reference records.
Research-use boundary: Research use only. Not for human or veterinary use. Public catalog information is limited to chemical identity, analytical documentation, and external reference records.
Public identity
- Publication state
- unpublished
- Sequence
- Leu-Leu-Gly-Asp-Phe-Phe-Arg-Lys-Ser-Lys-Glu-Lys-Ile-Gly-Lys-Glu-Phe-Lys-Arg-Ile-Val-Gln-Arg-Ile-Lys-Asp-Phe-Leu-Arg-Asn-Leu-Val-Pro-Arg-Thr-Glu-Ser
Available variants
| Size | SKU | Price (USD) | Availability | Representative purity |
|---|---|---|---|---|
| 5mg | DFP-019 | $0.00 | Out of stock | 99.1% |
Analytical boundary
Representative catalog purity: 99.1%
No active-batch certificate of analysis is currently published.
Purity figures shown here are representative catalog specifications, not lot-specific measurements.
Evidence inventory
- Record state
- reviewed records
- Public records
- 1851
- Reviewed summaries
- 184
- Verified citations
- 0
- Human study: 321
- In vivo: 339
- In vitro: 1190
- Special category: 0
- Unclassified: 1
These counts describe linked records and review status. They do not establish efficacy, safety, or fitness for any use.
Technical record
- Molecular weight
- 4493.3 Da
- Sequence class
- peptide
- Appearance
- Lyophilized Solid
- Solubility
- Water, PBS, or 0.9% NaCl
- Mechanism record
- LL-37 is the sole human cathelicidin antimicrobial chemical sequence, a 37-residue α-helical chemical sequence cleaved from hCAP-18 by proteinase 3. It directly kills bacteria via membrane pore formation (toroidal pore model), activates FPRL1 receptor-mediated chemotaxis of immune cells, stimulates angiogenesis via VEGF upregulation, and modulates TLR signaling. Active against Gram-positive, Gram-negative bacteria, and biofilms.
- Half-life record
- ~4 hours (IV); longer with AMP activity
Recorded receptors
- FPRL1
- P2X7
- bacterial membrane pore formation
External literature records
- External literature record
- External literature record
Limitations and research boundary
Research use only. Not for human or veterinary use. Public catalog information is limited to chemical identity, analytical documentation, and external reference records.
External records are attributed references. Their presence does not convert a source-reported observation into a product claim.