Research chemical sequence
Thymosin Beta-4 (TB500)
Thymosin Beta-4 (TB500) is listed as a research-use-only chemical sequence. Research use only. Not for human or veterinary use. Public catalog information is limited to chemical identity, analytical documentation, and external reference records.
Research-use boundary: Research use only. Not for human or veterinary use. Public catalog information is limited to chemical identity, analytical documentation, and external reference records.
Public identity
- Publication state
- unpublished
- Sequence
- Ac-Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu-Ile-Glu-Lys-Phe-Asp-Lys-Ser-Lys-Leu-Lys-Lys-Thr-Glu-Thr-Gln-Glu-Lys-Asn-Pro-Leu-Pro-Ser-Lys-Glu-Thr-Ile-Glu-Gln-Glu-Lys-Gln-Ala-Gly-Glu-Ser
- Molecular formula
- C205H337N57O63S
Available variants
| Size | SKU | Price (USD) | Availability | Representative purity |
|---|---|---|---|---|
| 10mg | DFP-046 | $0.00 | Out of stock | 99.5% |
Analytical boundary
Representative catalog purity: 99.5%
No active-batch certificate of analysis is currently published.
Purity figures shown here are representative catalog specifications, not lot-specific measurements.
Evidence inventory
- Record state
- reviewed records
- Public records
- 937
- Reviewed summaries
- 76
- Verified citations
- 0
- Human study: 59
- In vivo: 437
- In vitro: 441
- Special category: 0
- Unclassified: 0
These counts describe linked records and review status. They do not establish efficacy, safety, or fitness for any use.
Technical record
- CAS number
- 77591-33-4
- Molecular weight
- 4921.5 Da
- Sequence class
- peptide
- Molecular formula
- C205H337N57O63S
- Appearance
- White to off-white lyophilized powder
- Solubility
- Freely soluble in water and aqueous buffers. Reconstitute in sterile water or bacteriostatic water to 1-5 mg/mL. Stable at neutral pH.
- Mechanism record
- Thymosin Beta-4 is the principal intracellular G-actin sequestering protein (43 amino acids). Full mechanism includes G-actin binding via the LKKTETQ motif, PINCH-1/ILK/α-parvin complex activation for cardioprotection, Ac-SDKP anti-fibrotic activity (N-terminal cleavage product), HIF-1α stabilization for angiogenesis, and epicardial progenitor cell differentiation. Distinguished from its fragment TB-500 by engaging the FULL receptor profile including PINCH-1/ILK cardioprotection.
- Half-life record
- ~2-3 hours (plasma clearance)
Recorded receptors
- G-actin LKKTETQ (shared with TB-500)
- PINCH-1/ILK/α-parvin (cardioprotective. NOT in TB-500)
- Ac-SDKP anti-fibrotic
- HIF-1α angiogenesis
- epicardial progenitor differentiation
External literature records
- External literature record
- External literature record
Limitations and research boundary
Research use only. Not for human or veterinary use. Public catalog information is limited to chemical identity, analytical documentation, and external reference records.
External records are attributed references. Their presence does not convert a source-reported observation into a product claim.