Published study records

Study records for Epithalon

Study records describe published research and its limitations. They do not establish efficacy, safety, or suitability for any use.

Study record counts

168 study records.

2 evidence-verified · 133 citation-verified · 33 citation-only

Verified records by research setting

Human research: 14
In vitro: 31
In vivo/preclinical: 90
Review/meta-analysis: 0
Other: 0

Current study records

Study type: Human research · Status: Evidence verified by machine against declared source

Overview of Epitalon-Highly Bioactive Pineal Tetrapeptide with Promising Properties.

International journal of molecular sciences · 2025

Study scale: Not reported in the declared source.

Abstract only: Open source record

Product or molecular entity relationships

Epithalon: Exact entity relationship. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.

Summary withheld

No summary text is published for this record: the text held for each field did not answer the heading it was filed under. This does not change the record’s review status.

Research question

Not published. The text held for this field did not answer this heading, so nothing is shown here and nothing is substituted for it.

Study design

Not published. The text held for this field did not answer this heading, so nothing is shown here and nothing is substituted for it.

Key findings

Not published. The text held for this field did not answer this heading, so nothing is shown here and nothing is substituted for it.

Limitations and uncertainty

Not published. The text held for this field did not answer this heading, so nothing is shown here and nothing is substituted for it.

Product relevance and evidence boundary

This record is a published study, held here with its citation and review status. It is not a statement that any catalog item is effective, safe, or suitable for any use, and nothing in it is a dose or a protocol.

Evidence verified by machine against declared source. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.

Study type: In vitro · Status: Evidence verified by machine against declared source

Epitalon increases telomere length in human cell lines through telomerase upregulation or ALT activity.

Biogerontology · 2025

Study scale: IBR.3 cells were cultured in RPMI 1640 medium (Biosera) with 10% FBS (Gibco, Invitrogen) and 1% Penicillin–Streptomycin (Gibco).

Abstract only: Open source record

Product or molecular entity relationships

Epithalon: Exact entity relationship. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.

Public plain-language summary

The published text is limited to the declared source and preserves reported uncertainty. It does not establish efficacy, safety, suitability, or evidence strength.

Research question

This is the aim of our study.

Study design

It was shown to stimulate the proliferative capacity of epithelial cells (Khavinson et al 2003a, b) and fibroblast (Lin’kova et al 2016) in vitro thereby increasing the lifespan of the cells.

Participants or experimental system

Epitalon, a naturally occurring tetrapeptide, is known for its anti-aging effects on mammalian cells.

Study scale

IBR.3 cells were cultured in RPMI 1640 medium (Biosera) with 10% FBS (Gibco, Invitrogen) and 1% Penicillin–Streptomycin (Gibco).

Intervention or exposure

To try and reduce the burden of aging on society and to promote healthy aging, the pharmaceutical and supplement industries are identifying or re-purposing drugs for anti-aging intervention.

Comparator

Untreated cells were included to serve as a baseline control.

Outcomes examined

Critically short telomeres prevent cell cycling and proliferation, eventually leading to cellular senescence.

Key findings

In this article, the breast cancer cell lines 21NT, BT474, and normal epithelial and fibroblast cells were treated with epitalon then DNA, RNA, and proteins were extracted. qPCR and Immunofluorescence analysis demonstrated dose-dependent telomere length extension in normal cells through hTERT and telomerase upregulation.

Limitations and uncertainty

It is important to note that the qPCR method used measures average telomere lengths across all chromosomes, which represents a limitation of the actual technique.

Product relevance and evidence boundary

Study type: In vitro · Status: Citation identity verified

Epitalon-activated telomerase enhance bovine oocyte maturation rate and post-thawed embryo development.

Life sciences · 2025

Study scale: Not reported in the declared source.

Citation only: Open source record

Product or molecular entity relationships

Epithalon: Catalog source association. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.

No public summary

No plain-language summary is published in this record. Summary availability is separate from its review status. Consult the cited publication when a public link is available.

Limitations and uncertainty

Not reported in the declared source.

Citation identity verified. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.

Study type: In vitro · Status: Citation identity verified

Epitalon increases telomere length in human cell lines through telomerase upregulation or ALT activity

Research Square · 2025

Study scale: Not reported in the declared source.

Citation only: Open source record

Product or molecular entity relationships

Epithalon: Catalog source association. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.

No public summary

No plain-language summary is published in this record. Summary availability is separate from its review status. Consult the cited publication when a public link is available.

Limitations and uncertainty

Not reported in the declared source.

Citation identity verified. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.

Study type: In vitro · Status: Citation identity verified

The Antioxidant Tetrapeptide Epitalon Enhances Delayed Wound Healing in an in Vitro Model of Diabetic Retinopathy.

Stem cell reviews and reports · 2025

Study scale: Not reported in the declared source.

Citation only: Open source record

Product or molecular entity relationships

Epithalon: Catalog source association. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.

No public summary

No plain-language summary is published in this record. Summary availability is separate from its review status. Consult the cited publication when a public link is available.

Limitations and uncertainty

Not reported in the declared source.

Citation identity verified. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.

Study type: Human research · Status: Citation identity verified

[Peptidergic regulation of expression of cellular aging marker proteins in buccal epithelium.].

Advances in gerontology = Uspekhi gerontologii · 2024

Study scale: Not reported in the declared source.

Citation only: Open source record

Product or molecular entity relationships

Epithalon: Catalog source association. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.

No public summary

No plain-language summary is published in this record. Summary availability is separate from its review status. Consult the cited publication when a public link is available.

Limitations and uncertainty

Not reported in the declared source.

Citation identity verified. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.

Study type: In vitro · Status: Citation identity verified

Short Peptides Protect Fibroblast-Derived Induced Neurons from Age-Related Changes.

International journal of molecular sciences · 2024

Study scale: Not reported in the declared source.

Citation only: Open source record

Product or molecular entity relationships

Epithalon: Catalog source association. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.

No public summary

No plain-language summary is published in this record. Summary availability is separate from its review status. Consult the cited publication when a public link is available.

Limitations and uncertainty

Not reported in the declared source.

Citation identity verified. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.

Study type: In vitro · Status: Citation identity verified

Epitalon protects against post-ovulatory aging-related damage of mouse oocytes in vitro.

Aging · 2022

Study scale: Not reported in the declared source.

Citation only: Open source record

Product or molecular entity relationships

Epithalon: Catalog source association. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.

No public summary

No plain-language summary is published in this record. Summary availability is separate from its review status. Consult the cited publication when a public link is available.

Limitations and uncertainty

Not reported in the declared source.

Citation identity verified. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.

Study type: Human research · Status: Citation identity verified

[Age features of bioregulatory therapy of dental diseases.].

Advances in gerontology = Uspekhi gerontologii · 2020

Study scale: Not reported in the declared source.

Citation only: Open source record

Product or molecular entity relationships

Epithalon: Catalog source association. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.

No public summary

No plain-language summary is published in this record. Summary availability is separate from its review status. Consult the cited publication when a public link is available.

Limitations and uncertainty

Not reported in the declared source.

Citation identity verified. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.

Study type: In vitro · Status: Citation identity verified

Effect of short peptides on neuronal differentiation of stem cells.

International journal of immunopathology and pharmacology · 2019

Study scale: Not reported in the declared source.

Citation only: Open source record

Product or molecular entity relationships

Epithalon: Catalog source association. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.

No public summary

No plain-language summary is published in this record. Summary availability is separate from its review status. Consult the cited publication when a public link is available.

Limitations and uncertainty

Not reported in the declared source.

Citation identity verified. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.

Study type: In vitro · Status: Citation identity verified

Computer modeling of interaction of lysine dendrimer with epithalon peptides

Scientific and Technical Journal of Information Technologies, Mechanics and Optics · 2018

Study scale: Not reported in the declared source.

Citation only: Open source record

Product or molecular entity relationships

Epithalon: Catalog source association. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.

No public summary

No plain-language summary is published in this record. Summary availability is separate from its review status. Consult the cited publication when a public link is available.

Limitations and uncertainty

Not reported in the declared source.

Citation identity verified. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.

Study type: In vitro · Status: Citation identity verified

[GENOMIC VARIABILITY IN PATIENTS WITH DUCTAL FORM OF BREAST CANCER AND THE POSSIBILITY OF CORRECTION THE PEPTIDE BIOREGULATOR AND METAL IONS].

Georgian medical news · 2017

Study scale: Not reported in the declared source.

Citation only: Open source record

Product or molecular entity relationships

Epithalon: Catalog source association. Legacy citation custody associates this source with the catalog record; no product-relevance conclusion is implied.

No public summary

No plain-language summary is published in this record. Summary availability is separate from its review status. Consult the cited publication when a public link is available.

Limitations and uncertainty

Not reported in the declared source.

Citation identity verified. Verification is limited to the declared source and review scope. It does not mean independent replication or establish efficacy, safety, or suitability.